Activity of Ceftolozane-Tazobactam (C/T) against Escherichia coli Isolates from U.S. Veterans in Relation to Co-resistance and Sequence Type 131 (ST131) H30/H30Rx Status

Activity of Ceftolozane-Tazobactam (C/T) against Escherichia coli Isolates from U.S. Veterans in Relation to Co-resistance and Sequence Type 131 (ST131) H30/H30Rx Status

Escherichia coli sequence type 131 (ST131) subclone H30 as an emergent multidrug-resistant pathogen among US veterans.

BACKGROUND Escherichia coli sequence type 131 (ST131), typically fluoroquinolone-resistant (FQ-R) and/or extended-spectrum β-lactamase (ESBL)-producing, has emerged globally. We assessed its prevalence and characteristics among US veterans. METHODS In 2011, 595 de-identified E. coli clinical isolates were collected systematically within 3 resistance groups (FQ-susceptible [FQ-S], FQ-R, and ES...

Susceptibility to Alternative Oral Antimicrobial Agents in Relation to Sequence Type 3 ST131 Status and Co-resistance Phenotype Among Recent Escherichia coli Isolates

AAC 00650-13 version 2 1 2 Susceptibility to Alternative Oral Antimicrobial Agents in Relation to Sequence Type 3 ST131 Status and Co-resistance Phenotype Among Recent Escherichia coli Isolates 4 from U.S. Veterans 5 6 James R. Johnson, Sarah M. Drawz, Stephen Porter, and Michael A. Kuskowski 7 8 Veterans Affairs Medical Center, Minneapolis, MN, and University of Minnesota, 9 Minneapolis, MN 10...

Virulence of Escherichia coli clinical isolates in a murine sepsis model in relation to sequence type ST131 status, fluoroquinolone resistance, and virulence genotype.

Escherichia coli sequence type ST131 (O25b:H4) has emerged over the past decade as a globally disseminated, multidrug-resistant pathogen. Unlike traditional antimicrobial-resistant E. coli, ST131 derives from virulence-associated phylogenetic group B2 and exhibits extraintestinal virulence factors. This, plus preliminary evidence of virulence in experimental animals, has suggested that ST131's ...

342Epidemiology of Escherichia coli Sequence Type 131 in a Veterans Affairs Medical Center

342. Epidemiology of Escherichia coli Sequence Type 131 in a Veterans Affairs Medical Center Dimitri M. Drekonja, MD, MS; Brian Johnston, BA; Stephen Porter; Connie Clabots; Ruth Amway, RN; Michael A. Kuskowski, PhD; James R. Johnson, MD; Infectious Diseases, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN; Veterans Affairs Medical Center and University of Minnesota, Minneapoli...